A witch is first seen attacking the car of Carmine at the beginning of the game. It uses magic to manipulate a few stone statues, which causes the car to crash. The witch flees when the police arrives.
Some time later, after talking to Professor Layton, Espella is kidnapped by a Witch, destroying the Professor's office in the process, it flies off towards Tower Bridge. Layton and Luke chase after it through London until they find Inspector Chelmey and Barton on the bridge, investigating a car crash.